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1. With spatial biology tools, scientists welcome a new era of cell atlases
2. The Rise of Spatial Biology: Why a Better Approach Is Needed
3. Molecular Cartography™ of brain organoids to unravel the spatial logic of neural tissue development

Molecular Cartography™ of brain organoids to unravel the spatial logic of neural tissue development

Benedict Nilges², Ilaria Chiaradia¹, Richa Das², Andreas Geipel², Christian Korfhage², Frank Reinecke², Madeline A. Lancaster¹, Nachiket Kashikar²

¹MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, United Kingdom
²Resolve Biosciences GmbH, Creative Campus, Monheim am Rhein, Germany

Key Findings

• Resolve Biosciences’ Molecular Cartography™ platform reliably captures spatiotemporal gene expression through the segregation of neuronal layers during neurogenesis in Embryonic Stem Cell (ESC)-derived human organoids. This paves the way for studying key aspects of human brain development in vitro.
• Spatial gene expression analysis of the classical outer radial glia cell (oRG) markers in brain organoids call into question the selectivity of these markers and highlights the need to adopt new oRG-specific markers for evolutionary studies.
• Molecular cartography enables exploration of spatial gene expression changes in diverse cell subpopulations through a variety of developmental stages in brain organoids.

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