Press Releases

  1. Resolve Biosciences to Showcase Agrigenomic Applications for Molecular Cartography™ Platform at Advances in Genome Biology and Technology Agriculture Meeting. April 4, 2022
  2. Resolve Biosciences Joins EMBL’s Corporate Partnership Programme. Dec. 9, 2021
  3. Resolve Biosciences Appoints Oliver Dick as Chief Operating Officer. Dec. 01, 2021
  4. Announcing the Winners of The Scientist’s Top 10 Innovations of 2021. Dec. 01, 2021
  5. Resolve Biosciences Strengthens Leadership Team with Appointment of Frank Zhong as Chief Technology Officer. Nov. 2, 2021
  6. Resolve Biosciences Appoints Erik Wiberg as Chief Financial Officer. Sept. 13, 2021
  7. Resolve Biosciences and ZEISS Announce Co-Development Collaboration to Enhance Highest-Resolution View of Subcellular Spatial Biology. Aug. 3, 2021
  8. Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression. June 2, 2021
  9. Resolve Biosciences Announces Initial Results from Early Access Collaborations with Scientists Leading the Next Generation of Subcellular Spatial Analysis. Feb. 22, 2021
  10. Resolve Biosciences Launches New Era in Single-Cell Spatial Analysis. Dec. 10, 2020

Resolve Biosciences to Showcase Agrigenomic Applications for Molecular Cartography™ Platform at Advances in Genome Biology and Technology Agriculture Meeting

Six leading agricultural scientists will share new insights gained from the highest-resolution view of subcellular spatial biology

SAN DIEGO and MONHEIM AM RHEIN, Germany – April 4, 2022 – Resolve Biosciences, the pioneer in Molecular Cartography™, today announced a lineup of customer presentations at the inaugural Advances in Genome Biology and Technology (AGBT) Agriculture Meeting in San Diego on April 4-6, 2022. Meeting attendees will be able to learn more about the technology in booth #304 and hear six leading international scientists present data on how they are applying the power of the Molecular Cartography spatial transcriptomics technology to identify pathways that disrupt and advance agricultural genomics research.

“Resolve Biosciences’ pioneering Molecular Cartography technology is enabling the global scientific community to analyze highly complex formalin-fixed paraffin-embedded plant samples at subcellular resolution and gain valuable insights that are not possible with other single-cell or spatial biology platforms,” said Jason T. Gammack, co-founder and CEO of Resolve Biosciences. “We are proud to be working with all of these visionary scientists who are pushing the boundaries of agricultural genomics to help improve and increase sustainable food production.”

Featured Presentations

Resolve’s Molecular Cartography platform is the only spatial biology platform suitable for highly complex plant samples. The platform currently delivers the highest-resolution view of transcriptomic activity and provides the ability to interrogate hundreds of genes in a single run. Unlike other current approaches, the Resolve platform provides the required sensitivity, specificity, and workflow convenience to elucidate a cell’s complex transcriptional landscape. The technology produces deep contextual data sets that illuminate molecular interactions at subcellular resolution while preserving the sample tissue. The intuitive bioinformatics workflow can be easily integrated with other widely used spatial biology analysis tools.

Resolve Biosciences is also the premier gold sponsor of the upcoming AGBT General Meeting, which has been rescheduled for June 6-9, 2022. The company will unveil its commercial Molecular Cartography platform during the meeting and more than 20 leading biologists, virologists, and other scientists will be presenting data on how they are using the innovative technology to resolve a wide variety of complex biological challenges.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography™ to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, infectious disease, and agriculture. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences.

Media Contacts

Resolve Biosciences
Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences Joins EMBL’s Corporate Partnership Programme

Single-cell spatial analysis pioneer continues to invest in initiatives that train and support the next generation of molecular life scientists

MONHEIM AM RHEIN, Germany – Dec. 9, 2021 – Resolve Biosciences, the pioneer in Molecular Cartography™, today announced a corporate partnership with the European Molecular Biology Laboratory (EMBL). As part of the EMBL’s Corporate Partnership Programme (CPP), Resolve Biosciences will support molecular life science training. The financial support will enable young researchers to attend scientific conferences and courses, where they can present exciting new discoveries, and interact with scientific leaders from around the globe.

EMBL is the leading life science laboratory in Europe with more than 80 independent research groups covering the spectrum of molecular biology. The CPP was founded in 2009 to support collaboration and training for the next generation of molecular life scientists. The programme aims to connect industry leaders with leading molecular life scientists and biomedical researchers.

“EMBL warmly welcomes Resolve Biosciences to our Corporate Partnership Programme, and we look forward to working together to offer more inclusive access to our world-leading advanced scientific training for scientists who may otherwise be unable to participate,” said Edith Heard, EMBL Director General. “EMBL was established nearly 50 years ago to promote and enhance the life sciences across Europe, and the CPP plays an important role by helping support the development and promotion of innovative and groundbreaking scientific events in Europe.”

“EMBL is a world-renowned center for excellence known for its ongoing commitment to identifying, supporting, and training the next generation of scientists. The team at Resolve Biosciences is proud to continue this legacy and be part of EMBL’s Corporate Partnership Programme,” said Jason T. Gammack, Co-founder and CEO of Resolve Biosciences. “Spatial biology is the new frontier in biomedical research, and we look forward to enabling more researchers to apply the power of our groundbreaking Molecular Cartography technology to resolve the most daunting challenges in biology.”

For more information on EMBL’s Corporate Partnership Programme, please visit
https://www.embl.org/about/info/support/embl-corporate-partnership-programme.

About European Molecular Biology Laboratory

EMBL is Europe’s flagship laboratory for the life sciences. We are an intergovernmental organisation established in 1974 and are supported by 27 member states, two prospective member states and an associate member state. EMBL performs fundamental research in molecular biology, studying the story of life. We offer services to the scientific community; train the next generation of scientists and; strive to integrate the life sciences across Europe. We are international, innovative and interdisciplinary. We are more than 1,800 people, from more than 80 countries, operating across six sites in Barcelona (Spain), Grenoble (France), Hamburg (Germany), Heidelberg (Germany), Hinxton (UK) and Rome (Italy). Our scientists work in independent groups and conduct research and offer services in all areas of molecular biology. Our research drives the development of new technology and methods in the life sciences. We work to transfer this knowledge for the benefit of society. For more information, please visit www.embl.org.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through Resolve Biosciences’ commercial service laboratory. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contacts

Resolve Biosciences
Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences Appoints Oliver Dick as Chief Operating Officer

Renowned global operations and manufacturing executive will drive excellence and scale business to meet growing demand for the company’s Molecular Cartography™ system

MONHEIM AM RHEIN, Germany – Dec. 1, 2021 – Resolve Biosciences, the pioneer in Molecular Cartography™, today announced the appointment of Oliver Dick, PhD, as Chief Operating Officer. In this role, Dick will report to Co-founder and CEO Jason T. Gammack. He will be responsible for overseeing and scaling the company’s strategic planning, manufacturing, supply chain, quality control, information technology, and logistics functions to meet growing worldwide demand for the company’s groundbreaking Molecular Cartography platform for high-resolution spatial biology.

“As a startup company with a transformative spatial transcriptomic technology, one of our most important areas of focus is scaling the business as quickly and robustly as possible to take advantage of the tremendous opportunity we see in the market today. Oliver’s operational experience will help us achieve that goal much faster,” said Gammack. “I have worked closely with Oliver in the past and have been inspired by his commitment to operational excellence. His expertise and leadership will be instrumental as we position the company and our proprietary Molecular Cartography platform for long-term success.”

Dick is an experienced leader who has spent more than 30 years in the life sciences, pharmaceutical, and diagnostics industries. He recently served as Chief Operating Officer at Miltenyi Biotec, where he was responsible for developing and deploying the company’s growth strategy. Prior to that, Dick spent more than 12 years at QIAGEN where he was Vice President of Global Manufacturing for Life Sciences and Diagnostics. He was responsible for all engineering, procurement, logistics, manufacturing, and quality control functions at QIAGEN’s production facilities around the world. In this capacity, he also oversaw the integration of many successful acquisitions and continuously optimized processes to improve technology programs and reduce overall costs of goods. Prior to joining QIAGEN, Dick held management positions at Rentschler Biotechnologies, Pharmaplan, and the Pall Corporation. Dick received his PhD in chemical and bioprocess engineering from TU Dortmund University.

“Resolve Biosciences is poised to push the boundaries of spatial analysis and lead this next era in modern molecular biology,” said Dick. “Together, we will implement robust operational processes to help scale the business, drive efficiencies, and pursue excellence across the entire organization. We will make sure the Resolve Biosciences brand will be known for its high-quality precision engineering, reliability, and commitment to a world-class customer experience.”

Oliver Dick’s appointment completes Resolve’s leadership team. Over the past year, the company announced the appointment of Chris Barbazette as Chief Commercial Officer, Frank Zhong as Chief Technology Officer, and Erik Wiberg as Chief Financial Officer. Scientists interested in learning more about the innovative Molecular Cartography services can contact the Resolve team.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through Resolve Biosciences’ commercial service laboratory. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contacts

Resolve Biosciences
Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Announcing the Winners of The Scientist’s Top 10 Innovations of 2021

The Scientist 2021 - Top 10 Innovations Winner

Each year The Scientist seeks to highlight the latest and greatest tools, technologies, and techniques to hit the life science landscape. For more than a decade, we’ve been employing the assistance of expert panels of independent judges who weigh submissions of innovative products speeding work in laboratories and facilitating biological discovery. This year’s crop of entries to The Scientist’s Top 10 Innovations contest reflected the fact that the scientific community, like the whole of society, has been adjusting to a new reality marked by the second year of an extremely challenging and taxing global pandemic. At the same time, work in other areas of the life sciences has preserved. “In a way, it’s heartening that scientific advances have continued to occur in spaces outside of the crucial coronavirus focus,” says Editor-in-Chief Bob Grant. “It suggests that the global biomedical apparatus is robust enough to address a pressing and pointed concern while not losing ground in fields not directly related to that crisis.”

The winners of The Scientist’s Top 10 Innovations of 2021 contest are:

  1. nVueTM System (Inscopix) – This “miniaturized microscope” enables dual color imaging of two distinct brain signals in freely-behaving animals, such as two neuronal populations or neural activity in conjunction with brain blood flow.
  2. PhysioMimixTM Multi-Organ System (CN Bio) – The microfluidic platform allows scientists to connect individual organ-on-a-chip models for disease research and drug development.
  3. MERSCOPETM (Vizgen) – This single-cell spatial genomics instrument, the only one currently available for purchase, detects RNA transcripts from hundreds of genes across intact tissue and returns imaging and expression data at subcellular resolution.
  4. Brain-Chip (Emulate) – This organ-on-a-chip model consists of two channels embedded in flexible rubber polymer—one channel represents blood vessel walls and the other represents the brain—and midway along the chip, the two channels come into contact, allowing scientists to study the blood-brain barrier.
  5. Gemini and Mark I (Q Bio) – The Mark I prototype scans the entire body using magnetic resonance imaging (MRI), and the imaging results are uploaded to the Gemini platform, along with medical records, genetics data, and traditionally acquired tests of blood, urine, saliva, and vital signs, to create a “digital twin” of the patient.
  6. Chromium X (10X Genomics) – Loading cells, reagents, and a partitioning oil into a microfluidic chip, researchers can use this benchtop instrument to create droplets, or Gel Bead-In-Emulsions (GEMs), that each contain a single cell, a single barcoded Gel Bead, and a reagent, and are ready to be sequenced and used in assays offered by 10x Genomics.
  7. SARS-CoV-2 Neutralization Assay Development Kits (The Native Antigen Company) – This coronavirus neutralization assay uses synthetic versions of the SARS-CoV-2 spike protein’s receptor binding domain and its target, the mammalian ACE-2 receptor, to quantify a serum sample’s level of antibodies that bind, and therefore neutralize, the virus, as evidenced by a color change.
  8. Tapestri Single-cell Multi-omics Solution (Mission Bio) – This process for single-cell analysis allows users to consider DNA sequence and proteomic information simultaneously, and therefore correlated at the single-cell level.
  9. CRISPR-SNP-Chip (Cardea Bio) – Equipped with a CRISPR-Cas system tethered to a graphene transistor, this device is the first of its kind that can detect single base differences in DNA without generating millions of copies of the DNA first.
  10. Molecular CartographyTM Single-Cell Spatial Analysis Service (Resolve Biosciences) – This mail-in service offers fluorescence in situ hybridization (FISH) to create high-resolution images of individual RNA transcripts inside intact tissues—down to the subcellular level.

Congratulations to this year’s winners. Be sure to visit https://www.the-scientist.com/features/2021-top-10-innovations-69438 where you can read more about the products that earned top spots and see comments from our expert judges.

About The Scientist

The Scientist is a publication for life science professionals that is dedicated to covering a wide range of biological fields. The Scientist provides print and online coverage of the latest developments in the life sciences, including trends in research, new technology, news, business, and careers. It is read by the science-curious public and leading researchers in industry and academia who value penetrating analyses and broad perspectives on life science topics both within and beyond their areas of expertise. Written by prominent scientists and professional journalists, articles in The Scientist are concise, accurate, accessible, and entertaining.


Resolve Biosciences Strengthens Leadership Team with Appointment of Frank Zhong as Chief Technology Officer

Former product innovator at BGI, Illumina, and Pacific Biosciences will spearhead technological development of breakthrough Molecular Cartography™ system

MONHEIM AM RHEIN, Germany – Nov. 2, 2021 – Resolve Biosciences, the pioneer in Molecular Cartography™, today announced the appointment of Frank Zhong, PhD, as Chief Technology Officer. In this role, Zhong will report to Co-founder and CEO Jason T. Gammack and be responsible for overseeing all product development and advanced research activities that drive the company’s groundbreaking Molecular Cartography platform for high-resolution spatial biology.

“Over the past year, Resolve Biosciences has made tremendous strides as a business. We have built a world-class team, strengthened our footprint on two continents, and launched our commercial Molecular Cartography service offering,” said Gammack. “I am pleased to welcome Frank to our team, where his perspective and expertise in implementing industry-leading technologies will be invaluable as we look to push the boundaries of our Molecular Cartography platform and enable more customers to gain a deeper understanding of biological mechanisms, interactions, and complexity.”

Zhong brings to Resolve more than 20 years of experience conducting life science research and developing innovative genomic analysis tools for premier biotechnology companies. He recently served in senior leadership roles at the BGI Group, including CEO of EGI Inc., CTO of BGI Research USA, and Vice President of Advanced Research at Complete Genomics, where he assembled a global development team for the next-generation sequencing and automation products, including an integrated sample-to-result benchtop platform. Prior to working at BGI, Zhong was Associate Director of Technology Development at Illumina Inc., where he focused on advanced technology and systems, including the company’s first integrated semiconductor sensor-based platform, iSeq. Before that, he served in a series of system development roles at Pacific Biosciences, Inc., where he worked on optical systems and invented silicon photonics technology for the company’s single-molecule, real-time sequencing platforms. Zhong received his PhD in applied physics and master of science degree in electrical engineering from the University of Michigan. He also studied physics at Peking University in China before he moved to the USA.

“Spatial biology is an exciting new frontier in biomedical research that pairs innovative approaches with adjacent technologies and builds on many advances from DNA sequencing and single-cell genomics,” said Zhong. “Resolve’s Molecular Cartography platform uniquely provides researchers with the highest-resolution view of subcellular transcriptomic activity and the required sensitivity, specificity, and workflow convenience to answer complex biological questions that we’ve never been able to ask. I’m proud to be a part of this visionary team and look forward to expanding the company’s foundational research and development efforts to create new tools that will transform our understanding of complex biological systems.”

Frank Zhong is the latest addition to Resolve’s executive team. The company also recently announced the appointment of Chris Barbazette as Chief Commercial Officer and Erik Wiberg as Chief Financial Officer. Scientists interested in learning more about the innovative Molecular Cartography services can contact the Resolve team.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through Resolve Biosciences’ commercial service laboratory. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contacts

Resolve Biosciences
Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences Appoints Erik Wiberg as Chief Financial Officer

Experienced senior leader brings proven track record of developing financial strategies that drive operational excellence and accelerate global expansion

MONHEIM AM RHEIN, Germany – Sept. 13, 2021 – Resolve Biosciences, the pioneer in Molecular Cartography™, today announced the appointment of Erik Wiberg as Chief Financial Officer. In this role, Mr. Wiberg will report to Co-founder and CEO Jason T. Gammack and be responsible for the company’s finance, legal, human resources, and administrative functions.

“Resolve Biosciences is building a world-class team featuring top entrepreneurial talent from Silicon Valley with leading genomics and precision engineering experts in Germany,” said Mr. Gammack. “Erik is an extraordinary leader with a strong track record of developing and implementing comprehensive financial strategies for early-stage growth companies. His broad industry experience and passion for cutting-edge science make him a perfect fit for Resolve as we look to accelerate growth, drive operational excellence, and position the company for long-term commercial success.”

Mr. Wiberg brings more than 30 years of experience, including CFO roles at public and private firms in the medical device and biotechnology industries. Prior to joining Resolve, he served as CFO at REVA Medical, a leading provider of bioresorbable polymer technologies for vascular applications. He also held the CFO and Vice President of Administration position at Gyros Protein Technologies AB, as well as senior finance leadership positions at Thermo Fisher Scientific, AlliedSignal, and the Chamberlain Group. Mr. Wiberg holds a bachelor of science degree in mechanical engineering from the University of California, San Diego, as well as a master’s degree in machine vision and optics and an MBA from the University of California, Los Angeles.

“Resolve offered a unique, life-changing opportunity to join an international company that is poised to lead the next generation in molecular analysis,” said Mr. Wiberg. “I’m looking forward to relocating to Germany, working with this exceptional team of professionals, and enabling more scientists to apply the power of Molecular Cartography to resolve some of the most complex challenges in biology.”

Scientists interested in learning more about the innovative Molecular Cartography services can contact the Resolve team.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through Resolve Biosciences’ commercial service laboratory. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contacts

Resolve Biosciences
Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences and ZEISS Announce Co-Development Collaboration to Enhance Highest-Resolution View of Subcellular Spatial Biology

Molecular Cartography™ platform features leading microscopy and 3D imaging capabilities

MONHEIM AM RHEIN and JENA, Germany – Aug. 3, 2021 – Resolve Biosciences, the pioneer in Molecular Cartography™, and ZEISS today announced a co-development collaboration to advance spatial biology applications. The companies are working together to optimize advanced microscopy and 3D imaging solutions for subcellular spatial analysis. ZEISS microscopy technology is part of Resolve’s current Molecular Cartography service offering and will be incorporated into the commercial spatial transcriptomics system scheduled to launch later this year.

Resolve’s Molecular Cartography platform enables scientists to resolve the most complex biological challenges in areas such as oncology, neuroscience and infectious disease. Through this collaboration, ZEISS and Resolve Biosciences will combine leading optical technologies and engineering expertise with multi-analyte and highly multiplexed spatial analysis to illuminate molecular interactions at subcellular resolution while preserving the sample tissue. The companies will work together to enhance the Molecular Cartography workflow through the development of novel optical systems and computational approaches.

“This collaboration with Resolve Biosciences will enable scientists to achieve the highest-quality results in an integrated workflow with optimized throughput,” said Michael Albiez, Head of ZEISS Research Microscopy Solutions. “As the next frontier of biological research, spatial analysis presents the perfect opportunity to apply our advanced microscopy solutions for the clearest view of biological systems. We are committed to working with the Resolve team to allow more researchers to gain new insights in subcellular spatial biology.”

Resolve’s Molecular Cartography platform has been under development since 2016 and is currently available through a commercial service offering to researchers in Europe and North America. Unlike other current approaches, the Resolve platform provides the required sensitivity, specificity and workflow convenience to elucidate a cell’s complex transcriptional landscape. The technology produces deep contextual data sets that illuminate molecular interactions at subcellular resolution while preserving the sample tissue. Resolve’s Molecular Cartography platform currently delivers the highest-resolution view of transcriptomic activity and provides the ability to interrogate hundreds of genes in a single run. Future iterations of the technology will add DNA, protein and metabolomic data layers.

“Through this alliance, we now have access to key resources to scale our services business and are well on our way to providing our customers with a complete commercial system that features the latest advances in German precision engineering,” said Jason T. Gammack, Co-founder and CEO of Resolve Biosciences.

About ZEISS

ZEISS is an internationally leading technology enterprise operating in the fields of optics and optoelectronics. In the previous fiscal year, the ZEISS Group generated annual revenue totaling 6.3 billion euros in its four segments Semiconductor Manufacturing Technology, Industrial Quality & Research, Medical Technology and Consumer Markets (status: 30 September 2020).

For its customers, ZEISS develops, produces and distributes highly innovative solutions for industrial metrology and quality assurance, microscopy solutions for the life sciences and materials research, and medical technology solutions for diagnostics and treatment in ophthalmology and microsurgery. The name ZEISS is also synonymous with the world’s leading lithography optics, which are used by the chip industry to manufacture semiconductor components. There is global demand for trendsetting ZEISS brand products such as eyeglass lenses, camera lenses and binoculars.

With a portfolio aligned with future growth areas like digitalization, healthcare and Smart Production and a strong brand, ZEISS is shaping the future of technology and constantly advancing the world of optics and related fields with its solutions. The company’s significant, sustainable investments in research and development lay the foundation for the success and continued expansion of ZEISS’ technology and market leadership. ZEISS invests 12 percent of its revenue in research and development – this high level of expenditure has a long tradition at ZEISS and is also an investment in the future.

With over 34,000 employees, ZEISS is active globally in almost 50 countries with around 30 production sites, 60 sales and service companies and 27 research and development facilities. Founded in 1846 in Jena, the company is headquartered in Oberkochen, Germany. The Carl Zeiss Foundation, one of the largest foundations in Germany committed to the promotion of science, is the sole owner of the holding company, Carl Zeiss AG (status: 31 March 2021).

Further information at www.zeiss.com

ZEISS Research Microscopy Solutions
ZEISS Research Microscopy Solutions is the world’s only one-stop manufacturer of light, electron, X-ray and ion microscope systems and offers solutions for correlative microscopy. The portfolio comprises of products and services for life sciences, materials and industrial research, as well as education and clinical practice. The unit is headquartered in Jena. Additional production and development sites are located in Oberkochen and Munich, as well as in Cambourne (UK) and Dublin (USA). ZEISS Research Microscopy Solutions is part of the Industrial Quality & Research segment.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through Resolve Biosciences’ commercial service laboratory. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contacts

Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com

ZEISS Research Microscopy Solutions
Vybhav Sinha
+49 3641 64-3949
press.microscopy@zeiss.com


Resolve Biosciences Launches Commercial Molecular Cartography™ Services to Provide Scientists with Highest-Resolution View of Subcellular Gene Expression

Company expands global footprint with opening of US facility and appoints industry veteran Chris Barbazette to lead rapidly growing commercial organization

MONHEIM AM RHEIN, Germany, and SAN JOSE, Calif. – June 2, 2021 – Resolve Biosciences today announced the commercial launch of its groundbreaking Molecular Cartography™ service offering to provide scientists with the highest-resolution view of subcellular gene expression. Through this new service offering, customers in North America and Europe will be able to submit their samples of interest for analysis and receive data back from Resolve’s technical team. To help meet the significant global demand for its next-generation spatial analysis technology, Resolve is expanding capabilities in Europe and has opened a North American facility in San Jose, Calif. In addition, Resolve has appointed Chris Barbazette as Chief Commercial Officer to lead the company’s growing sales and marketing operations.

Under development since 2016, Resolve’s Molecular Cartography platform consists of proprietary, highly multiplexed, single-molecule detection technology to measure transcriptomic activity with full spatial context at subcellular resolution. During the past year, the technology has demonstrated groundbreaking capabilities in several high-profile early access collaborations to better understand human brain development, cell type evolution, and how the SARS-CoV-2 infection affects neighboring cells over time. Unlike other spatial analysis techniques, the Resolve platform provides the required sensitivity and specificity to elucidate a cell’s complex transcriptional landscape. The technology generates deep contextual data sets that illuminate molecular interactions while preserving sample tissue for future analysis.

“We believe the power of spatial biology lies in enabling a deeper understanding of biological mechanisms, interactions, and complexity,” said Jason T. Gammack, Co-founder and CEO of Resolve Biosciences. “After the resounding success of our early access program, we are now delivering our innovative Molecular Cartography services to leading institutions throughout the US and Europe.”

Global Footprint and Commercial Operations Expansion
To help support the global demand for its Molecular Cartography services, Resolve is rapidly expanding its team and opening a new state-of-the-art office and laboratory in San Jose. The new facility will augment the company’s German headquarters and provide regional support to the company’s growing customer base in North America. Chris Barbazette, who brings a proven track record of introducing disruptive technologies and directing successful global commercial organizations, will oversee the new facility and commercial operations around the world.

Mr. Barbazette previously held senior commercial positions at GenapSys, Agendia, and Affymetrix. As Senior Vice President of Global Commercial Operations at Affymetrix, he was responsible for building a robust worldwide distribution network that brought the latest genotyping and gene expression solutions to customers in more than 40 countries.

“Resolve Biosciences has the right team and technology platform to lead the next generation of genomic analysis. Molecular Cartography provides high-resolution spatial context and adds a valuable new dimension to scientific research that enables a better understanding of biological mechanisms and functions,” said Mr. Barbazette. “I’m looking forward to supporting our growing customer base and empowering them with tools to provide insights that will transform life sciences research and, eventually, clinical diagnostics.”

Scientists interested in learning more about the innovative Molecular Cartography services can contact the Resolve team.

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of spatial biology. The platform features the company’s proprietary, highly multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a fully automated workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through Resolve Biosciences’ commercial service laboratory. Resolve Biosciences is privately held and based in Monheim am Rhein, Germany, with a North American facility and laboratory in San Jose, Calif. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contact

Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences Announces Initial Results from Early Access Collaborations with Scientists Leading the Next Generation of Subcellular Spatial Analysis

The power and resolution of the Molecular Cartography™ platform is illuminating important cellular interactions in COVID-19 pathology, neurology, and developmental biology research

MONHEIM AM RHEIN, Germany – Feb. 22, 2021 – Resolve Biosciences, the pioneer in Molecular Cartography™, today announced initial results from several prominent early access collaborations with leading laboratories across Europe. Teams of scientists are currently using the groundbreaking subcellular spatial analysis technology to help resolve daunting challenges in COVID-19 pathology, neurology, and developmental biology research.

SARS-CoV-2-transcript
SARS-CoV-2 transcripts of the nucleocapsid protein (shown in yellow) are predominantly found close to the cell nucleus. Interestingly, some cells show a polar localization of SARS-CoV-2 transcripts (red arrows). Transcripts of 80 other genes (marked in different colors) are distributed throughout the cell. The Resolve Biosciences Molecular Cartography™ technology enabled scientists to compare infected and non-infected cells to understand subcellular gene regulation and how the infection affects neighboring cells over time.

Under development since 2016, Resolve’s Molecular Cartography platform features the company’s proprietary, highly multiplexed, single-molecule detection technology to provide the highest-resolution view of subcellular transcriptomic activity. Unlike other spatial analysis techniques, the Resolve platform provides the required sensitivity, specificity, and workflow convenience to elucidate the cell’s complex transcriptional landscape. The technology generates deep contextual data sets that illuminate molecular interactions at subcellular resolution while preserving the sample tissue for future analysis.

The Resolve Molecular Cartography platform has been available through an oversubscribed early access program during the past year. Initial findings from several of the high-profile projects include:

  • SARS-CoV-2 Infection and Inflammatory Response — Medical University of Graz, Austria
    The laboratory led by Kurt Zatloukal, MD, Professor of Pathology and Head of the Diagnostic and Research Center for Molecular Biomedicine, is using the Molecular Cartography platform to study the molecular pathology behind SARS-CoV-2 infection and the subsequent inflammatory response on the mRNA level that leads to severe disease. The Resolve technology offers the ability to explore the distribution of infected cells, their morphology, and molecular activity at the same time. The team analyzed different cell culture systems to compare the transcriptomic activity of more than 80 genes in infected cells and non-infected cells, explore how cells react to changes in gene expression upon viral infection, analyze the exact position of transcripts within cells, and investigate how the antiviral host response can trigger tissue damage. The initial results have provided a better understanding of subcellular gene regulation and how the infection affects neighboring cells over time.
  • Human Brain Development — MRC Laboratory of Molecular Biology, Cambridge, UK
    Madeline A. Lancaster, PhD, Group Leader in the Cell Biology Division, and her team are applying the power of Molecular Cartography to brain organoids to unravel the spatial logic of neural tissue development. Since the technology reliably captures spatiotemporal gene expression, researchers can study key aspects of human brain function and development in vitro. The team used the technology to detect and quantify expression with ultra-high sensitivity, showing 100 gene transcripts simultaneously at subcellular resolution. The initial results suggest that the spatial distribution of mRNA molecules for outer radial glia (oRG) cell markers is not confined to the outer subventricular zone but rather is spread throughout the whole proliferative ventricular zone. This observation highlights the necessity to look for more specific oRG markers to be applied in the context of brain organoids.
  • Retina Gene Expression and Cell Type Evolution — University College London, UK
    Ryan MacDonald, PhD, Biotechnology and Biological Sciences Research Council David Phillips Fellow and Lecturer at the Institute of Ophthalmology, and his colleagues are using Molecular Cartography technology to better understand how a healthy retina develops and changes with advancing age. Scientists were able to visualize the spatial expression of 48 genes simultaneously in the same zebrafish sample to observe the development of different cell types using specific marker genes in the retina. Then by visualizing gene expression changes over the entire lifespan, specifically within the support cells called glia, they were able to identify candidate genes that are dysregulated in the aging retina and potentially underlie progressive neuronal degeneration and vision loss.

“Thanks to its exquisite resolution, the technology from Resolve Biosciences allows us to detect specific gene expression patterns in SARS-CoV-2 that we could not see with existing RNA sequencing or single-cell RNA-seq technologies,” said Prof. Zatloukal. “Since the Resolve workflow provides spatial information at subcellular resolution and still preserves the tissue integrity, we see clear clinical opportunities with this approach moving forward.”

“Over the past year, Resolve Biosciences has had the privilege of working with many of the true visionaries of single-cell and spatial biology,” said Jason T. Gammack, Co-founder and CEO of Resolve Biosciences. “We are grateful for their engagement and feedback, and proud that they were able to gain new insights that were not possible with alternative approaches. We look forward to empowering more scientists around the world with this same ability to rapidly advance the understanding of complex biology with our novel Molecular Cartography platform.”

Resolve Biosciences is now expanding its early access program globally. Scientists interested in learning more about how to access and apply the power of its innovative Molecular Cartography technology can contact the company. 

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of single-cell spatial biology. The platform features the company’s proprietary, multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through an oversubscribed early access program. Resolve Biosciences is privately held and headquartered in Monheim, Germany. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contact

Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com


Resolve Biosciences Launches New Era in Single-Cell Spatial Analysis

Company announces $24 million Series A financing and appoints Jason T. Gammack as CEO to accelerate development and commercialization of Molecular Cartography™ platform

MONHEIM AM RHEIN, Germany – Dec. 10, 2020 – Resolve Biosciences, the pioneer in Molecular Cartography™, announced the completion of a $24 million Series A financing round and the appointment of Co-founder Jason T. Gammack as Chief Executive Officer.

Detection of 500,000 mRNA Transcripts from 100 different genes in a mouse cortex tissue using Resolve Biosciences’ Molecular Cartography™ platform.
Credentials: Resolve Biosciences, Courtesy of Araks Martirosyan (Matthew Holt lab, VIB-KU Leuven, Belgium)

The company’s Molecular Cartography platform is a groundbreaking multi-analyte and highly multiplex spatial analysis technology that enables scientists to resolve the most daunting biological challenges in areas such as oncology, neuroscience, and infectious disease. It produces deep contextual data sets that illuminate molecular interactions at subcellular resolution, while preserving the sample tissue. The initial applications of Resolve’s Molecular Cartography platform deliver the highest-resolution view of transcriptomic activity and provide the ability to interrogate hundreds of genes in a single run. Future solutions will add DNA, protein, and metabolomic data layers. Unlike current approaches, Resolve’s technology provides the required sensitivity, specificity, and workflow convenience to elucidate the cell’s complex transcriptional landscape.

Series A Financing

The Series A financing round was led by PS Capital Management and MasterMind Advisory Services and included participation from Alafi Capital, John Shoffner, and High Tech GrĂĽnderfonds. The company will use the proceeds to accelerate product development and drive industry adoption of its Molecular Cartography technology.

“Molecular Cartography creates a new dimension of spatial analysis, which will soon expand the frontiers of modern molecular biology. Our innovative solution enables valuable scientific insights that far exceed the reach of legacy spatial biology technologies,” said Peer M. Schatz, Chairman and Co-founder of Resolve Biosciences. “Jason is an accomplished leader in the field of advanced genomics, and I’m looking forward to working with him again to help Resolve Biosciences transform the future of life sciences research and clinical diagnostics.”

CEO Appointment

Jason T. Gammack brings more than 25 years of life sciences industry experience and has developed successful product and customer engagement strategies for some of its preeminent biotechnology brands. He recently served as Chief Commercial Officer at Inscripta, where he oversaw sales, marketing, business development, and customer support for the company’s CRISPR-enabled Onyx™ Digital Genome Engineering platform. Before that, he was Vice President of the Life Science Business at QIAGEN, where he led the life science portfolio and go-to-market strategy. Earlier in his career, Gammack developed commercialization growth strategies at Ingenuity Systems, a leading bioinformatics company acquired by QIAGEN in 2013. He has also held senior leadership roles at Sigma-Aldrich, Invitrogen/Life Technologies, Affymetrix, and Promega Corporation.

“Resolve Biosciences’ pioneering Molecular Cartography platform powers novel insights by enabling scientists to gain the highest-resolution view of subcellular gene expression activity,” said Gammack. “Together with our talented team of scientists and investors, we are poised to lead the next generation of single-cell analysis and support scientists around the world as they apply the latest advances of our Molecular Cartography technology platform to solve the most complex biological questions.”

About Resolve Biosciences

Resolve Biosciences is applying the power of Molecular Cartography to enable scientists to gain new insights based on the highest-resolution view of single-cell spatial biology. The platform features the company’s proprietary, multiplexed, single-molecule detection technology, which offers full spatial context at subcellular resolution, all in a workflow that preserves the sample tissue. The Molecular Cartography technology offers unparalleled sensitivity and specificity that helps scientists detect individual transcripts and rare signals to interpret fundamental biology and rapidly advance the understanding of complex biological questions in critical fields such as oncology, neuroscience, and infectious disease. The technology has been under development since 2016 and is currently available through an oversubscribed early access program. Resolve Biosciences is privately held and headquartered in Monheim, Germany. For additional information, visit www.resolvebiosciences.com.

Resolve Biosciences, the Resolve Biosciences logo, and Molecular Cartography are trademarks of Resolve Biosciences Inc.

Media Contact

Andrew Noble
+1 (415) 722-2129
andrew@bioscribe.com

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