Scientists have been aware that spatial context matters in biology. Long before they had the technology to provide detailed data, there was an acceptance that biological microenvironments, or niches of cell populations, were significant. Interactions among cells, proteins, and expressed genes depended heavily on how close they were to one another. To understand the why in biology, it is important to understand the where, what, and when of the molecular components that determine the biology. Spatial biology aims to provide that information.