Navigating the brain using spatial transcriptomics in health, disease and development

Speakers: Lynette Lim, PhD & Jeroen Aerts, PhD

Elucidating cellular heterogeneity and the transcriptomic programs that shape neuronal diversity and circuit assembly is crucial to understanding the underlying neurobiology in health, disease and development.

Using Molecular CartographyTM, we quantified changes in transcriptomic activity and cellular phenotypes in response to Alzheimer’s disease pathology. This multiplexed, single-molecule detection technology also allows for the transcriptomic characterization of rare GABAergic interneurons in the developing mouse cortex with full spatial context at subcellular resolution.

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